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Abstract #0435

Characterization of Hemodynamic Alterations in Autism using Resting State fMRI

Wenjing Yan 1 and Gopikrishna Deshpande 1,2

1 AU MRI Research Center,Department of Electrical and Computer Engineering, Auburn University, Auburn, Alabama, United States, 2 Department of Psychology, Auburn University, Alabama, United States

Functional MRI studies of Autism attribute all changes in the fMRI signal to underlying neural activity, assuming an unaltered hemodynamic response function (HRF) in Autism. However, recent evidence from molecular/cellular approaches indicates that some neurovascular alterations may exist in the autistic brain. Therefore, we hypothesized that voxel-wise HRF derived from blind deconvolution of resting state fMRI will be altered in the autistic brain. We found significant group differences in HRF parameters in the frontal, temporal and motor areas, indicating that alterations based on the fMRI signal in Autism cannot be entirely attributed to underlying neural activity.

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