Assessment of renal allograft fibrosis with magnetic resonance elastography in kidney transplantation patients
Nan Jiang 1 , General Leung 2,3 , Serge Jothy 4 , Darren A. Yuen 3,5 , and Anish Kirpalani 2,3
Faculty of Medicine, University of Toronto,
Toronto, ON, Canada,
of Medical Imaging, St. Michael's Hospital, University
of Toronto, Toronto, ON, Canada,
Research Centre, St. Michael's Hospital, Toronto, ON,
of Pathology, St. Michael's Hospital, Toronto, ON,
Division of Nephrology, St. Michael's
Hospital, Toronto, ON, Canada
Chronic allograft injury (CAI) is a devastating outcome
affecting 60% of kidney transplant patients at 10 years.
Fibrosis is the common pathway leading to CAI. We
compared stiffness values measured by MR elastography (MRE)
in renal allografts to fibrosis measured by biopsy, In
our pilot study of 8 patients, we found significant
increase in MRE-derived stiffness in allografts with
severe fibrosis compared to no, minimal, mild fibrosis
and moderate fibrosis. MRE may enable non-invasive
quantitative assessment of renal allograft fibrosis and
may be able to predict sites for targeted biopsy.
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