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Abstract #0480

Multimodal MR/PET imaging for characterization of hypoxia in human glioblastoma

Christine Preibisch 1,2 , Mathias Lukas 3 , Anne Kluge 1 , Severin Keinath 3 , Vivien Tth 1,4 , Kuangyu Shi 3 , Thomas Pyka 3 , and Stefan Frster 3

1 Department of Neuroradiology, Klinikum rechts der Isar der TU Mnchen, Munich, Germany, 2 Clinic for Neurology, Klinikum rechts der Isar der TU Mnchen, Munich, Germany, 3 Department of Nuclear Medicine, Klinikum rechts der Isar der TU Mnchen, Munich, Germany, 4 Department of Radiology, Klinikum rechts der Isar der TU Mnchen, Munich, Germany

Preliminary multimodal MR/PET data from 18 patients with glioblastoma are presented with the aim of a comprehensive characterization of tumor pathophysiology. A semi-quantitative BOLD-based parameter, related to vascular de-oxygenation, termed relative oxygen extraction fraction (rOEF), was acquired simultaneously with 18F-FET PET, which has been shown to be valuable for detecting highly malignant tumor tissue. In a small subgroup of four patients, hypoxia related 18F-FMISO PET was acquired. These preliminary data support the utility of 18F-FET and rCBV as markers for viable malignant tumor tissue. With respect to hypoxia, more patient data and more sophisticated analyses are clearly needed.

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