Multimodal MR/PET imaging for characterization of hypoxia in human glioblastoma
Christine Preibisch 1,2 , Mathias Lukas 3 , Anne Kluge 1 , Severin Keinath 3 , Vivien Tth 1,4 , Kuangyu Shi 3 , Thomas Pyka 3 , and Stefan Frster 3
Department of Neuroradiology, Klinikum
rechts der Isar der TU Mnchen, Munich, Germany,
for Neurology, Klinikum rechts der Isar der TU Mnchen,
of Nuclear Medicine, Klinikum rechts der Isar der TU
Mnchen, Munich, Germany,
of Radiology, Klinikum rechts der Isar der TU Mnchen,
Preliminary multimodal MR/PET data from 18 patients with
glioblastoma are presented with the aim of a
comprehensive characterization of tumor pathophysiology.
A semi-quantitative BOLD-based parameter, related to
vascular de-oxygenation, termed relative oxygen
extraction fraction (rOEF), was acquired simultaneously
with 18F-FET PET, which has been shown to be valuable
for detecting highly malignant tumor tissue. In a small
subgroup of four patients, hypoxia related 18F-FMISO PET
was acquired. These preliminary data support the utility
of 18F-FET and rCBV as markers for viable malignant
tumor tissue. With respect to hypoxia, more patient data
and more sophisticated analyses are clearly needed.
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