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Abstract #0499

Performance of Bi-Component T2* Fitting of Bound and Pore Bone Water Fractions is Dependent on Field Strength

Alan C. Seifert 1 , Suzanne L. Wehrli 2 , and Felix W. Wehrli 1

1 University of Pennsylvania, Philadelphia, PA, United States, 2 Children's Hospital of Philadelphia, Philadelphia, PA, United States

Discrimination between bound and pore bone water is vital for quantification of bone matrix density and porosity. The two main approaches are T2-selective magnetization preparation and bi-exponential T2* fitting. T2* of pore water, however, is shortened by field gradients arising from the difference in susceptibility between water and bone. We scanned human cortical bone specimens at 4 field strengths, and validated bi-exponential fitting against CT porosity and gravimetrically-determined matrix density. Our results indicate that T2* bi-exponential fitting of FIDs may be a suitable method for quantifying bound and pore water fractions at 1.5T, but may fail at higher field strengths.

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