Effects of Real-time fMRI Neurofeedback of the Amygdala Specific to Major Depressive Disorder
Vadim Zotev 1 , Kymberly D. Young 1 , Raquel Phillips 1 , Masaya Misaki 1 , and Jerzy Bodurka 1,2
Laureate Institute for Brain Research,
Tulsa, OK, United States,
of Engineering, University of Oklahoma, Tulsa, OK,
We have investigated effects of real-time fMRI
neurofeedback (rtfMRI-nf) targeting the left amygdala
(LA) to identify changes in LA functional connectivity
that correlate with depression severity (HDRS). Thirteen
MDD patients learned to upregulate their LA activity
using rtfMRI-nf during a positive emotion induction task
based on retrieval of happy autobiographical memories.
We observed a significant positive correlation between
the LA connectivity enhancement across rtfMRI-nf runs
and HDRS for several key brain regions including the
rostral anterior cingulate cortex (rACC) and mediodorsal
thalamus. Our results suggest that rtfMRI-nf holds
ability to correct the LA functional connectivity
impairments specific to MDD.
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