Probing metabolite diffusion at ultra-short diffusion times in the mouse brain using optimized oscillating gradients and a short echo time strategy
Clemence Ligneul 1,2 , Chlo Najac 1,2 , Julien Flament 1,3 , and Julien Valette 1,2
URA 2210, Fontenay-aux-Roses, France,
US27, CRC-MIRCen, Fontenay-aux-Roses, France
Measuring diffusion at ultra-short td may yield
information about short-range obstacles and cytosol
viscosity. However, reaching such td usually requires
oscillating gradients, which in turn imply long echo
times TE. Here we propose a new kind of stretched
oscillating gradients that allow increasing b while
preserving spectral and temporal properties of the
gradient modulation. We then use these optimized
gradients to measure metabolite diffusion in the mouse
brain down to td=1 ms while keeping TE relatively short.
The strong macromolecule signal can be used as an
internal reference of null diffusivity, allowing us to
discard spectra corrupted by motion artifacts.
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