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Abstract #0620

Towards a refined bi-compartmental model of brain metabolism using bonded cumomers analysis of 13 C MRS spectra

Brice Tiret 1,2 , Vincent Lebon 1,2 , Julien Valette 1,2 , and Pierre-Gilles Henry 3

1 CEA/DSV/I2BM/MIRCen, Fontenay-aux-Roses, France, 2 CNRS, URA 2210, Fontenay-aux-Roses, France, 3 CMRR, Minneapolis, MN, United States

13 C MRS together with labeled substrate infusion is a minimally invasive technique used to probe the TCA cycle. Despite previous efforts, traditional models fail to explain individual isotopomer (or more precisely, bonded cumomers) dynamics. Using a rapid model screening method, it becomes possible to use previously untapped information given by bonded cumomers to improve the bi-compartmental model. Such improvements include adding a vesicular glutamate pool and a double dilution of labeled plasmatic pyruvate.

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