Abstract #0633
Human placental and fetal response to maternal hyperoxygenation in IUGR pregnancy as measured by BOLD MRI
Jie Luo 1 , Esra Abaci Turk 1 , Tobias Hahn 1 , Mara Teuln Gonzlez 1,2 , Borjan Gagoski 3 , Carolina Bibbo 4 , Arvind Palanisamy 5 , Clare M Tempany-Afdhal 6 , ngel Torrado-Carvajal 1,7 , Norberto Malpica 1,7 , Judith Martnez Gonzlez 8 , Julian N Robinson 4 , Juan A Hernndez-Tamames 1,7 , Elfar Adelsteinsson 1,9 , and Patricia Ellen Grant 3
1
Madrid-MIT M+Vision Consortium in RLE,
Massachusetts Institute of Technology, Cambridge, MA,
United States,
2
Department
of Obstetrics and Gynecology, Hospital Universitario de
Fuenlabrada, Madrid, Spain,
3
Fetal-Neonatal
Neuroimaging & Developmental Science Center, Boston
Children's Hospital, Harvard Medical School, Boston, MA,
United States,
4
Department
of Obstetrics and Gynecology, Division of Maternal and
Fetal Medicine, Brigham and Womens Hospital, Boston,
MA, United States,
5
Department
of Anaesthesia, Brigham and Women's Hospital, Boston,
MA, United States,
6
Department
of Radiology, Brigham and Womens Hospital, Boston, MA,
United States,
7
Medical
Image Analysis and Biometry Laboratory, Universidad Rey
Juan Carlos, Madrid, Spain,
8
Department
of Radiology, Hospital Universitario de Fuenlabrada,
Madrid, Spain,
9
Department
of Electrical Engineering and Computer Science,Harvard-MIT
Health Sciences and Technology, Massachusetts Institute
of Technology, Cambridge, MA, United States
Adequate oxygen transport across the placenta from
mother to fetus is critical for fetal growth and
development. Clinical assessment of placental
insufficiency relies on Doppler ultrasound. BOLD MRI can
detect oxygenation changes in the placenta and fetal
organs during maternal hyperoxygenation in healthy human
subjects. In addition maternal hyperoxygenation has
successfully differentiated rat intrauterine growth
restriction (IUGR) models from normal, indicating a
potential in detecting and monitoring human IUGR. In
this study, we have characterized for the first time
functionally different placental regions and fetal
response to maternal hyperoxygenation in an IUGR
pregnancy.
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