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Abstract #0642

In-utero localized diffusion MRI of the embryonic mouse brain microstructure and injury

Dan Wu 1 , Jun Lei 2 , Jason Rosenzweig 2 , Irina Burd 2 , and Jiangyang Zhang 3

1 Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States, 2 Gynecology and Obstetrics, Johns Hopkins University School of Medicine, Maryland, United States, 3 Radiology, Johns Hopkins University School of Medicine, Maryland, United States

In vivo diffusion MRI (dMRI) of the embryonic mouse brain is extremely challenging due to the complex motion and the demand for high-resolution to resolve the early brain microstructures. We proposed a localized imaging technique to achieve 3D dMRI in a reduced field-of-view, using spatially selective excitation pulses. Motion was reduced with the fast imaging, and further corrected by navigator echoes and retrospective registration. We were able to delineate major white and gray matter structures in the normal at 0.2 mm isotropic resolution, and detect embryonic brain injury in a mouse model of intrauterine inflammation.

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