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Abstract #0648

Cell Volume Fraction (cell density) is Stable despite Cerebral Volume Loss in Normal Human Ageing as Measured by Quantitative Sodium MR Imaging at 9.4Tesla

Elaine H Lui 1,2 , Jonathan Guntin 3 , Saad Jamil 3 , Ziqi Sun 3 , Ian C Atkinson 3 , and Keith R Thulborn 3

1 Radiology, Royal Melbourne Hospital, University of Melbourne, Parkville, Victoria, Australia, 2 Centre of Magnetic Resonance Research, University of Illinois Chicago, Chicago, Illinois, United States, 3 Centre of Magnetic Resonance Research, University of Illinois Chicago, Illinois, United States

The age dependence of cell volume fraction (CVF) has been determined in normal human brain. CVF is derived from tissue sodium concentration (TSC) measured by quantitative sodium MRI at 9.4T using the flexible twisted projection sequence with 3-point calibration and the two-compartment model of tissue sodium distribution. Regional analysis provided descriptive statistics of CVF and voxel number for specified brain regions to use in a linear correlation analysis of their dependence on age. CVF remains stable across cognitively normal ageing despite progressive cerebral volume loss. This methodology may be useful for monitoring progression of neurodegenerative diseases prior to clinical manifestation.

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