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Abstract #0661

Application of native myocardial T1 mapping in subjects with coronary microvascular dysfunction and no obstructive coronary artery disease

Jaime L. Shaw 1,2 , Janet Wei 3 , Puja K. Mehta 3 , David Chen 1 , Michael Nelson 1,3 , Louise E.J. Thomson 3 , Daniel S. Berman 3 , C. Noel Bairey Merz 3 , Debiao Li 1,2 , and Behzad Sharif 1

1 Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, United States, 2 Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA, United States, 3 Cedars-Sinai Heart Institute, Los Angeles, CA, United States

Abnormally elevated myocardial native T1 values are known to suggest diffuse myocardial fibrosis. In this study, we hypothesized that native myocardial T1 would be abnormally elevated in subjects with signs and symptoms of ischemia, no obstructive coronary artery disease (CAD), and suspected coronary microvascular dysfunction (CMD). We measured myocardial native T1 in symptomatic women with no obstructed CAD enrolled in a single-site cohort of the NHLBI-sponsored WISE-Coronary Vascular Dysfunction study. Relative to published normal native T1 values, native T1 values in women with signs and symptoms of ischemia and no obstructive CAD were significantly elevated.

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