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Abstract #0669

Dynamic Contrast Enhanced MRI Estimate of Tumor Interstitial Fluid Pressure in Solid Brain Tumors

Madhava P Aryal 1 , Tavarekere N Nagaraja 2 , Rasha Elmghribi 1,3 , Kelly A Keenan 2 , Swayamprava Panda 1 , Glauber Cabral 1 , Stephen L Brown 4 , and James R Ewing 1,3

1 Dept. of Neurology, Henry Ford Hospital, Detroit, MI, United States, 2 Dept. of Anesthesiology, Henry Ford Hospital, Detroit, MI, United States, 3 Dept. of Physics, Oakland University, Rochester, MI, United States, 4 Dept. of Radiation Oncology, Henry Ford Hospital, Detroit, MI, United States

In many solid tumors an elevated tumor interstitial fluid pressure (TIFP) is a central and potentially critical element for assessing therapeutic response. The present study examined the possibility of evaluating TIFP non-invasively using dynamic contrast enhanced MRI (DCE-MRI) data in a rat model of cerebral glioma. A significant correlation between DCE-MRI derived TIFPs with those of WIN estimates (n=9, R=0.77, p≤0.02) was established. These data strongly demonstrate the possibility of employing DCE-MRI for non-invasive estimates of TIFP in solid tumors, and also provides a means for estimating fluid conductivity in tumor surround.

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