Abstract #0696
Genetically functionalized magnetosomes as MRI contrast agent suitable for molecular imaging
Marianne Boucher 1 , Nicolas Ginet 2 , Franoise Geffroy 1 , Sandra Prveral 2 , Graldine Adryanczyk-Perrier 2 , Michel Pean 2 , Christopher T Lefvre 2 , Daniel Garcia 2 , David Pignol 2 , and Sbastien Mriaux 1
1
UNIRS, CEA/DSV/I2BM/NeuroSpin, Saclay,
France,
2
LBC,
CEA/DSV/IBEB/SBVME, Saint-Paul-lez-Durance, France
Magnetosomes are iron nanocrystals embedded in a lipid
bilayer which are produced by magnetotactic bacteria. We
propose to demonstrate the efficiency of magnetosomes as
T
2
contrast
agent for MRI, and the feasibility of harvesting
functionalized magnetosomes from genetically modified
bacteria. RGD peptide, known for targeting α
ν
β
3
integrins,
has been chosen for functionalization and the affinity
of targeting magnetosomes is demonstrated with U87
cells. The contrasting properties of magnetosomes are
assessed by acquiring T
2
*w images prior and
after injection and comparing number of detected
hypointense voxels. Thus, magnetosomes possess MRI
sensitivity and α
ν
β
3
specificity
required for future molecular imaging experiments.
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