Abstract #0731
Utility of MR-Spectroscopy in early drug discovery: characterization of dynamic temporal metabolic changes following psychoactive challenges in the rodent brain
Sakthivel Sekar 1 , Sankar Seramani 1 , Joanne Garnell 1 , and Kishore Kumar Bhakoo 1
1
Translational Imaging Industrial Lab,
Singapore Bioimaging Consortium, Biopolis, Singapore
Our findings exemplify the utility of 1H-MRS in early
drug discovery, to non-invasively investigate the
dynamic metabolite temporal changes in the brain, to
further understand (or corroborate) the behavioral
effects of psychoactive compounds [Sekar et al., 2013]
and their functional activation(s) observed with other
Neuroimaging modalities (fMRI, rs-fMRI,
electrophysiology, etc) [Sekar et al., 2010, 2011, 2013]
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