Ketamine Improves Astroglial Metabolic Activity and Neurotransmission in Social Defeat Model of Depression: A 1 H-[ 13 C]-NMR Study
Pravin Kumar Mishra 1 and Anant Bahadur Patel 1
Centre for Cellular and Molecular Biology,
Astroglia play a major role in recycling and metabolism
of neurotransmitters at synapse. The functional
characteristics of astroglia is not well understood in
depression. Ketamine has been reported to possess rapid
anti-depressant activity. The objective of the current
study was to evaluate the astroglial metabolic activity,
and effects of ketamine in social defeat model of
depression. Depression led to reduction in the
astroglial metabolic activity. Moreover, sub-anesthetic
dose of ketamine was able to restore behavioral
phenotypes and astroglial activity in depressed mice.
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