Abstract #0741
Co-localized Post-Contractile BOLD and 31P-MRI in Muscles of the Lower Leg
Prodromos Parasoglou 1,2 , Ding Xia 1,2 , Jill M Slade 3,4 , and Ravinder R Regatte 1,2
1
Bernard and Irene Schwartz Center for
Biomedical Imaging, Department of Radiology, New York
University School of Medicine, New York, NY, United
States,
2
Center
for Advanced Imaging Innovation and Research (CAI2R),
Department of Radiology, New York University School of
Medicine, New York, NY, United States,
3
Department
of Radiology, Michigan State University, East Lansing,
MI, United States,
4
Biomedical
Imaging Research Center, Michigan State University, East
Lansing, MI, United States
Defects in muscle efficacy can result from reduced blood
supply, tissue oxygenation, and/or mitochondrial
dysfunction. Phosphorus (31P) MR can noninvasively
assess skeletal muscle bioenergetics, whereas
microvascular function in muscle can be measured using
BOLD MRI. However, given the limited tissue coverage of
most 31P-MR approaches, the two measurements are
typically obtained from different regions of the muscle.
In this study, we implemented a high-resolution 31P-MRI
method and combined it with BOLD MRI to obtain
co-localized post-contractile microvascular and
bioenergetics information in muscles of the lower leg of
healthy subjects following plantar flexion.
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