T 2 and T 1ρ detect early regenerative changes in ischemic skeletal muscle
Hanne Hakkarainen 1 , Galina Wirth 1 , Petra Korpisalo-Pirinen 1 , Seppo Yl-Herttuala 1 , and Timo Liimatainen 1,2
University of Eastern Finland, A.I. Virtanen
Institute for Molecular Sciences, Kuopio, Finland,
Center, Kuopio University Hospital, Kuopio, Finland
time constants were applied to differentiate areas of
early regeneration in a mouse hind limb ischemia model.
Percentages of areas having early signs of regeneration
and areas of other tissue morphologies were determined
based on T
the ischemic muscle cross section and correlations
between histology derived percentages were calculated.
able to detect the early regenerative areas making them
potential markers of activation of regeneration of
skeletal muscle tissue after ischemia.
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