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Abstract #0756

In vivo 37 Cl MRI of Human Calf Muscle at 7T

Judith Schork 1 , Anna Kollefrath 1 , Manuela B. Rsler 1 , Reiner Umathum 1 , and Armin M. Nagel 1

1 Medical Physics in Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany

Chloride (Cl - ) plays an important role in several physiological processes. However, due to the very short transverse relaxation times, quantitative measurements of 35 Cl are challenging. Although this isotope exhibits higher NMR sensitivity than 37 Cl, the 1.27-fold lower electrical quadrupole moment of 37 Cl results in longer relaxation times and could offer an imaging advantage over 35 Cl. To prove this effect a quadrature birdcage coil for 37 Cl MRI was built and used for in vivo and phantom measurements. This work shows the first 37 Cl in vivo images of a human calf muscle. For comparison of relaxation times, 35 Cl MRI was also performed.

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