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Abstract #0781

Monitoring therapeutic response on non-small cell lung cancer in chemotherapy by amide proton transfer (APT) imaging in mice

Keisuke Ishimatsu 1 , Shanrong Zhang 1 , Koji Sagiyama 1 , Osamu Togao 1 , Brenda Timmons 2 , John Minna 2 , and Masaya Takahashi 1

1 Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, Texas, United States, 2 Hamon Center for Therapeutic Oncology, Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, United States

The objective of our study is to investigate whether amide proton transfer (APT) imaging can be used for monitoring treatment responses of the lung cancer in chemotherapy. We compared temporal changes of APT signal in a non-small cell lung carcinoma with and without erlotinib which is a small molecule epidermal growth factor receptor tyrosine kinase inhibitor in mice.

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