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Abstract #0782

Dynamic Imaging of D-Glucose at 7T: First Experiments in Human Brain

Xiang Xu 1,2 , Craig K. Jones 1,2 , Nirbhay N. Yadav 1,2 , Linda Knutsson 3 , Jun Hua 1,2 , Rita Kalyani 4 , Erica Hall 4 , John Laterra 5 , Jaishri Blakeley 5 , Roy Strowd 5 , Prakash Ambady 5 , Martin Pomper 1 , Peter Barker 1,2 , Guanshu Liu 1,2 , Kannie W.Y. Chan 1,2 , Michael T. McMahon 1,2 , Robert D. Stevens 5,6 , and Peter van Zijl 1,2

1 Department of Radiology, Johns Hopkins University, Baltimore, MD, United States, 2 F. M. Kirby Research Center, Kennedy Krieger Institute, Baltimore, MD, United States, 3 Department of Medical Radiation Physics, Lund University, Lund, Sweden, 4 Division of Endocrinology, Diabetes, & Metabolism, Johns Hopkins University, Baltimore, MD, United States, 5 Department of Neurology, Johns Hopkins University, Baltimore, MD, United States, 6 Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University, Baltimore, MD, United States

Recent animal studies show that D-glucose is a potential biodegradable MRI contrast agent. Here, using chemical exchange saturation transfer (CEST) MRI, we show that it is possible to detect dynamic changes in the human brain at 7T during and after infusion of D-glucose. The dynamic glucose images provide information regarding blood arterial input function (AIF), tissue perfusion and glucose transport. We present data from both healthy volunteers and a brain tumor patient with anaplastic astrocytoma showing glucose enhancement in the tumor region. This method is promising for studying perfusion properties of tumors and the brain.

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