Optimizing multislice acidoCEST MRI for assessments of extracellular pH in tumor and kidney tissues.
Edward A Randtke 1 , Kyle Jones 1 , Christy Howison 1 , Julio Crdenas-Rodrguez 1 , and Mark D Pagel 1
Biological and Medical Imaging, University
of Arizona, Tucson, Arizona, United States
We have incorporated the Phase-Offset MultiPlanar (POMP)
Simultaneous MultiSlice (SMS) technique into CEST-FISP
MRI to create multislice acidoCEST MRI protocol that can
measure extracellular pH in 3D volumes of tumor and
kidney tissues. Gaussian filtering was critical for
improving CEST MRI for voixelwise analysis. The pHe
values in tumor and kidney tissues were measured using
Bloch-McConnell fitting of CEST spectra. Although
voxelwise pHe measurements have some variance, pHe
analyses of tissue and sub-tissue regions have excellent
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