Meeting Banner
Abstract #0789

Dynamic contrast-enhanced MR imaging in rectal cancer: study of inter-software accuracy and reproducibility using simulated and clinical data

Luc Beuzit 1 , Pierre-Antoine Eliat 2 , Elise Bannier 1,3 , Jean-Christophe Ferr 1,3 , Yves Gandon 1 , Vanessa Brun 1 , and Herv Saint-Jalmes 4,5

1 Radiology, CHU Rennes, Rennes, France, 2 PRISM-Biosit CNRS UMS 3480, INSERM UMS 018, University of Rennes I, Rennes, France, 3 Neurinfo MR imaging platform, University of Rennes I, Rennes, France, 4 Radiology, Eugne Marquis Cancer Institute, Rennes, France, 5 LTSI, UMR 1099, INSERM, University of Rennes I, Rennes, France

Dynamic contrast-enhanced MRI is a promising biomarker for investigating early tumor response, but is subject to numerous factors of variation. The purpose of this study was to assess the potential role of software packages in this variability. Using an original DICOM file processing method, we studied the accuracy of software packages for measuring pharmacokinetic parameters on simulated data. We showed significant errors for all five software packages studied, leading to poor inter-software agreement. A very poor agreement was observed among the software packages when processing clinical data consisting of dynamic contrast-enhanced MR images of rectal tumors.

This abstract and the presentation materials are available to members only; a login is required.

Join Here