Abstract #0799
Localized Detection of Fasting-Induced Changes in Lactate Metabolism By Hyperpolarized 13 C MRSI
Cornelius von Morze 1 , Gene-Yuan Chang 2 , Peder E Larson 1 , Hong Shang 1 , Robert A Bok 1 , Jason C Crane 1 , Marram P Olson 1 , C.T. Tan 3 , Sarah J Nelson 1 , John Kurhanewicz 1 , David Pearce 2 , and Daniel B Vigneron 1
1
Department of Radiology & Biomedical
Imaging, UCSF, San Francisco, California, United States,
2
Department
of Medicine, UCSF, San Francisco, California, United
States,
3
ISOTEC,
Sigma-Aldrich, Miamisburg, Ohio, United States
MRSI of hyperpolarized (HP)
13
C-labeled
compounds is a powerful new approach for localized
non-invasive studies of tissue metabolism in vivo. The
purpose of this study was to characterize
tissue-specific alterations in the metabolism of HP
gluconeogenic precursors
13
C-lactate
and
13
C-pyruvate
by rat liver and kidneys in response to fasting. Seven
rats were studied by 13C MRSI of both HP
13
C-lactate
and
13
C-pyruvate
in both normal fed and 24h fasting states. Significant
metabolic modulations associated with fasting were
identified in the localized metabolite data resulting
from these spectroscopic imaging experiments.
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