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Abstract #0830

Altered Cortical and Subcortical Functional Connectivity in a Single Football Season

Bryson B. Reynolds 1 , Todd M. Chatlos 1 , Donna K. Broshek 2 , Max Wintermark 3 , Susan F. Saliba 4 , Howard P. Goodkin 5 , and T. Jason Druzgal 1

1 Radiology and Medical Imaging, University of Virginia School of Medicine, Charlottesville, Virginia, United States, 2 Psychiatry and Neurobehavioral Sciences, University of Virginia School of Medicine, Charlottesville, Virginia, United States, 3 Radiology, Stanford School of Medicine, San Francisco, CA, United States, 4 Kinesiology, University of Virginia Curry School, Charlottesville, VA, United States, 5 Neurology, University of Virginia Health System, Charlottesville, VA, United States

Biomechanical head impact data shows that football players receive significantly more severe and more numerous subconcussive impacts than lacrosse players. Our data shows that in football players (N=21) there are significant increases in cortical-cortical functional connectivity and significant decreases in subcortical-cortical functional connectivity during the span of a season as measured by rs-fMRI (p<0.001), however there were no observed changes in lacrosse players during a practice season (N=30). Our preliminary data presents a compelling argument that rs-fMRI is capable of detecting and demonstrating physiologic changes in a single football season, likely caused by subconcussive impacts.

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