Multifunctional Liposome for Non-small Cell Lung Cancer Targeting and Theranostic MRI
Ren Lili 1 , Shizhen Chen 1 , Haidong Li 1 , Zhiying Zhang 1 , Jianping Zhong 1 , and Xin Zhou 1
National Center for Magnetic Resonance in
Wuhan, Wuhan Institute of Physics and Mathematics,
Wuhan, Hubei, China
A multifunctional liposome, which contained Gd-DOTA (MRI
probe), paclitexal (PTX) and c(RGDyk) (targeting
peptide), was prepared. This nanoparticle could utilize
the insolubility of PTX, reduce the side effect of
FDA-approved formulation of PTX-Cre (Taxol), and
improve the drug delivery efficiency to tumor.
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