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Abstract #0903

Iron and Non-iron Related Pathological Features of Multiple Sclerosis Lesions using Multiparametric 7T MRI

Sanjeev Chawla 1 , Ilya Kister 2 , Jens Wuerfel 3 , E Mark Haacke 4 , Tim Sinnecker 3 , Jean Christophe Brisset 1 , Friedemann Paul 3 , and Yulin Ge 1

1 Radiology, New York University Langone Medical Center, New York, NY, United States, 2 Neurology, New York University Langone Medical Center, New York, NY, United States, 3 Radiology, Universittsmedizin Gttingen, Berlin, Germany, 4 Radiology, Wayne State University, Detroit, Michigan, United States

To characterize multiple sclerosis (MS) lesions based on iron and non-iron related pathological features, twenty-one patients underwent GRE-T2* and high-resolution quantitative susceptibility mapping (QSM) imaging on 7T MR system. Three morphologically distinct lesion patterns were observed. Majority of the lesions (75.0%), were hyperintense on T2* images and inconspicuous on QSM (Pattern A), few lesions (9.56%) showed hyperintensity on both T2* and QSM (Pattern B). However, some lesions (15.5%) demonstrated hypointensity on T2*/SWI images and hyperintensity on QSM (Pattern C) indicating that that these lesions encompass predominant iron content. Ultra-high field MRI may provide insights into the pathogenesis of MS lesions.

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