USPIO Contrast Enhanced MRI Study Monitoring Inflammatory Lesions in Brain of the Relapsing-Remitting Model of EAE in SJL/J mice
Matthew Fronheiser 1 , Jenny Xie 1 , Elizabeth Heimrich 1 , Adrienne Pena 1 , Thomas Petrone 1 , Daniel Kukral 1 , Vojkan Susulic 1 , Harold Malone 1 , Patrick Chow 1 , Shuyan Du 1 , Feng Lu 1 , Wendy Hayes 1 , and Haiying Tang 1
Bristol Myers Squibb, Princeton, New Jersey,
In this work, ultrasmall superparamagnetic iron oxide
(USPIO) nanoparticle enhanced MRI techniques were used
to assess brain inflammatory lesions in a mouse model of
Relapsing-Remitting multiple sclerosis (MS). Three
groups (No disease, Disease No Treatment, Disease
Treatment) were studied at four time points to monitor
the relapsing and remitting phases of the disease.
Pixel-wise R2 and Change in R2 (ΔR2) maps were generated
to evaluate regions of increased USPIO uptake in the
brain. Our results showed that USPIO enhanced MRI can be
used to assess changes in the inflammatory lesion to
examine treatment effect in a MS mouse model.
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