Meeting Banner
Abstract #0908

Hippocampal-related memory network in Multiple Sclerosis: a structural connectivity analysis

Elisabetta Pagani 1 , Maria A. Rocca 1,2 , Sara Llufriu 1,3 , Gianna Carla Riccitelli 1 , Bruno Colombo 2 , Mariaemma Rodegher 2 , Andrea Falini 4 , Giancarlo Comi 2 , and Massimo Filippi 1,2

1 Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, MI, Italy, 2 Department of Neurology, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, MI, Italy, 3 Hospital Clinic Barcelona, Barcelona, E, Spain, 4 Department of Neuroradiology, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, MI, Italy

Memory dysfunction is frequently present in patients with multiple sclerosis and diffusion tensor imaging enables to define and quantify structural damage in networks involved in memory performance. In this study, we quantified structural connectivity integrity of the hippocampal-related episodic memory network and its association with memory performance in multiple sclerosis patients. We found that the network is globally impaired in patients, even if it maintains a configuration in which the thalamus and parietal lobes show the highest strength. The integrity of this network seems relevant for preserving memory functions.

This abstract and the presentation materials are available to members only; a login is required.

Join Here