Abstract #0911
BOLD, Blood Flow and Hypercapnic Challenge Reveals Cerebrovascular Decoupling in Multiple Sclerosis
Mark J. Lowe 1 , Wanyong Shin 1 , Lael Stone 2 , Robert Bermel 2 , and Micheal D. Phillips 1
1
Imaging Institute, Cleveland Clinic,
Cleveland, OH, United States,
2
Neurologic
Insititute, Cleveland Clinic, Cleveland, OH, United
States
It is known that multiple sclerosis results in decreased
cerebral metabolic rate of oxygen and blood flow. Both
of these are critical elements in cerebrovascular
reactivity to neuronal activation. Using simultaneous
BOLD/ASL, we measured BOLD activation during a visual
task and cerebrovascular reactivity using a hypercapnia
challenge in a cohort of multiple sclerosis patients and
matched control subjects. We show that the
cerebrovascular coupling is significantly different in
multiple sclerosis patients.
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