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Abstract #0924

Temporal-Variance Weighted P-space Multipole Frequency Mapping

Kyle S Decker 1,2 and Chunlei Liu 3,4

1 Center for In Vivo Microscopy, Duke University, Durham, NC, United States, 2 Biomedical Engineering, Duke University, Durham, NC, United States, 3 Brain Imaging and Analysis Center, Duke University, Durham, NC, United States, 4 Radiology, Duke University, Durham, NC, United States

Through the use of improved processing methods, we are able to use a single-shift p-space image reconstruction to produce high fidelity multipole frequency maps using multi-echo data. The temporal-variance of higher-order multipole frequency distribution is dominant in the white matter (WM), thus allowing the use of temporal-variance to enhance multipole frequency maps of WM in the p-space. This method suppresses artifacts in isotropic regions including gray matter and allows isolated characterization of sub-voxel WM anisotropy. The resulting temporal-variance weighted p-space multipole frequency maps provide a new contrast mechanism with enhanced WM anisotropy and contrast.

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