Enhanced T1-weighted myelin contrast across lamina at 7T; in-vivo, ex-vivo, and histology
Alessio Fracasso 1 , Susanne J van Veluw 2 , Fredy Visser 3,4 , Jaco JM Zwanenburg 4 , Serge O Dumoulin 1 , and Natalia Petridou 4
Experimental Psychology, Helmholtz
institute, Utrecht University, Utrecht, Netherlands,
Brain Center Rudolf Magnus, University Medical Center,
Medical Systems, Best, Netherlands,
Imaging Division, University Medical Center, Utrecht,
Myelin content can be estimated in vivo to identify a
large number of cortical areas, however extra-striate,
within-area myelination at sub-mm scale is harder to
visualize. Using a modified T1-w MPRAGE we visualize
striate and extra-striate laminar intensity variations
in in-vivo and ex-vivo data, comparing ex-vivo results
with histological sections. In-vivo, ex-vivo and
histology striate areas as well extra-striate cortex
showed a reliable, high-contrast structure around the
middle of cortical thickness in T1-w laminar profiles.
This structure likely represents the two separated lines
of Baillarger. This T1-w sequence provides the basis for
studying laminar structure in humans, in vivo.
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