Effect of hypobaric pressure on MRI parameters, including B0, T2, T2*, and T1
Eric R. Muir 1 , Damon P. Cardenas 1 , and Timothy Q. Duong 1
Research Imaging Institute, University of
Texas Health Science Center, San Antonio, TX, United
High-altitude, where air pressure and thus oxygen
content are reduced, could lead to a broad spectrum of
disorders in the brain, such as white matter
hyperintensity and brain swelling. Previous studies
investigated high altitude sickness post exposure.
Studies of the brain during hypobaric conditions could
lead to a better understanding of its effects. In this
work, we constructed an MRI-compatible hypobaric chamber
for animal MRI scanner and performed B0 and relaxation
time measurements during acute hypobaric exposure. B0
was slightly shifted under hypobaric pressure, and T2
and T2* were decreased under hypobaric air.
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