The number of subjects needed to detect a change in white matter microstructure depends on the pathway in question
Sonya Bells 1 , C John Evans 1 , and Derek K Jones 1
School of Psychology, CUBRIC, Cardiff,
Wales, United Kingdom
To be able to evaluate the differences in white matter
across time plays an important role in brain research.
We aim to estimate the sample size necessary to detect
changes within white matter tracts in a repeated
measures design. Three white matter sequences were
acquired (diffusion weighted, multi-component
relaxometry and non-Gaussian diffusion) to assess the
variance within 18 different white matter tracts, which
was then used in power calculations. Power calculations
varied between the different white matter sequences and
tracts. For example, detecting a 15% change within FA
for the uncinate 18 subjects are needed while in
cingulum-hippocampus it is 45.
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