Detection of brain macromolecules using double inversion recovery ultra-short acquisition delay 1 H MRSI at 7 Tesla
Michal Povaan 1 , Gilbert Hangel 1 , Bernhard Strasser 1 , Marek Chmelik 1 , Stephan Gruber 1 , Siegfried Trattnig 1 , and Wolfgang Bogner 1
MRCE, Department of Biomedical Imaging and
Image-guided therapy, Medical University Vienna, Vienna,
The 1H ultra-short acquisition delay spectra are
characterized by the superposition of signals of
metabolites and macromolecules. We have developed a
double inversion nulling method to measure
macromolecular spectra at 7T with acquisition delay as
short as 1.3 ms and very short repetition time (900 ms).
Optimal inversion times were simulated and
experimentally verified. Macromolecular spectra were
acquired from four young healthy volunteers. The spectra
did not exhibit any visible difference in inter-subject
comparison. In addition, four conventional 1H MRSI
datasets without inversion were acquired in healthy
subjects and quantified using basis sets with and
without incorporated macromolecules.
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