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Abstract #0998

Study of Bound Proton T2 and Magnetization Transfer using Pulsed MT

Xu Jiang 1,2 , Peter van Gelderen 1 , Xiaozhen Li 1 , Emily Leibovitch 3 , Pascal Sati 4 , Afonso C. Silva 5 , and Jeff H Duyn 1

1 AMRI, LFMI, NINDS, NIH, Bethesda, MD, United States, 2 Department of Physics, University of Maryland, College Park, MD, United States, 3 Viral Immunology Section, Neuroimmunology Branch, NINDS, NIH, Bethesda, MD, United States, 4 Translational Neuroradiology Unit, NINDS, NIH, Bethesda, MD, United States, 5 CMU, LFMI, NINDS, NIH, Bethesda, MD, United States

Accurate knowledge of the T2 of bound (non-water) protons is very essential for optimization and quantification of MT contrast. Using optimized, 2ms long binomial MT pulses with varying amplitudes, and studying delay-dependent saturation of mobile water protons, we determined bound proton T2 to average 27μs, 17.5μs and 13.5μs in white matter, grey matter, and muscle tissue in marmoset in vivo, while the exchange rates between water and non-water protons were 13s-1, 30s-1, and 47s-1 respectively. The pulse-delay approach followed here proved a sensitive way to study MT contrast and is applicable to study of human brain at high field.

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