Quantification of Myocardial Blood Flow using Non-ECG-Triggered MR Imaging with 3 Slice Coverage
David Chen 1,2 , Behzad Sharif 1 , Xiaoming Bi 3 , Janet Wei 4 , Louise E.J. Thomson 4,5 , C. Noel Bairey Merz 5 , Daniel S Berman 1,4 , and Debiao Li 1,6
Biomedical Imaging Research Institute,
Cedars Sinai Medical Center, Los Angeles, CA, United
Engineering, Northwestern University, Evanston, IL,
R&D, Siemens Healthcare, Los Angeles, CA, United States,
Mark Taper Foundation Imaging Center, Cedars Sinai
Medical Center, Los Angeles, CA, United States,
Streisand Women's Center, Cedars Sinai Medical Center,
Los Angeles, CA, United States,
Geffen School of Medicine, University of California, Los
Angeles, CA, United States
A single-bolus non-ECG-triggered method for quantifying
myocardial blood flow is described. Beat-by-beat T1
mapping is used to derive the true arterial input
function, eliminating the need for an additional scan.
The imaging workflow is further simplified by
retrospectively determining the proper reconstruction
window, eliminating the dependency on ECG triggering.
MBF values were validated compared to conventional
dual-bolus ECG-triggered method. Stress studies were
also performed to identify feasibility at elevated heart
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