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Abstract #1025

Joint estimation of microstructural and biomechanical features of the brain using a phase sensitive reconstruction of DWIs

Tim Sprenger 1,2 , Jonathan I. Sperl 2 , Axel Haase 1 , Brice Fernandez 3 , Christopher Hardy 4 , Luca Marinelli 4 , Michael Czisch 5 , Philipp Saemann 5 , and Marion I. Menzel 2

1 IMETUM, Technical University, Munich, Germany, 2 GE Global Research, Munich, Germany, 3 GE Healthcare, Munich, Germany, 4 GE Global Research, Niskayuna, NY, United States, 5 Max Planck Institute of Psychiatry, Munich, Select, Germany

Diffusion weighted magnetic resonance imaging (DWI) allows for non-invasive measurement of microstructural features of the human brain. Usually all data processing in DWI is based on the magnitude of the complex MR signal, and the inherent phase of the signal is discarded as it is considered to be spoiled by different sources. One source for a non-zero phase in DWI signal is the pulsation of the brain itself, which is potentially impacted by disorders such as hydrocephalus or traumatic brain injury. In this work, a phase correction approach is introduced to sequentially remove all phase contributions except for brain pulsation.

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