Fractional Ventilation Mapping using Inert Fluorinated Gas MRI in a Rat Model of Inflammation
Marcus J. Couch 1,2 , Matthew S. Fox 3,4 , Chris Viel 1,2 , Gowtham Gajawada 1,2 , Tao Li 2 , and Mitchell S. Albert 1,2
Lakehead University, Thunder Bay, Ontario,
Bay Regional Research Institute, Thunder Bay, Ontario,
Research Institute, London, Ontario, Canada,
of Medical Biophysics, Western University, London,
F MR imaging was performed in a rat model
of pulmonary inflammation using SF
Fractional ventilation maps and ventilation gradients
were compared between controls and rats that were
instilled with lipopolysaccharide. Ventilation gradients
calculated from control rats showed the expected
gravitational relationship, while ventilation gradients
calculated from LPS-instilled rats showed the opposite
trend. Inflammation may disrupt the expected gradient in
lung compliance, and elevated alveolar wall thicknesses
in LPS-instilled rats were confirmed by histology.
MRI may be able to detect the presence of inflammation
using a simple and inexpensive approach that can
potentially be translated to humans.
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