Abstract #1044
Hypoxia modification during prostate radiotherapy: an evaluation of changes in the tumour microenvironment using multi-parametric MRI (mpMRI)
N Jane Taylor 1 , Kent Yip 2 , Juliette Valentine 2 , J James Stirling 1 , Ian C Simcock 1 , David J Collins 3 , James A d'Arcy 3 , Uma Patel 2 , Andrew Gogbashian 1 , Peter Hoskin 2 , Anwar R Padhani 1 , and Roberto Alonzi 2
1
Paul Strickland Scanner Centre, Mount Vernon
Hospital, London, United Kingdom,
2
Marie
Curie Research Wing, Mount Vernon Cancer Centre, London,
United Kingdom,
3
Cancer
Research-UK-EPSRC Cancer Imaging Centre, Institute of
Cancer Research and Royal Marsden NHS Foundation Trust,
Sutton, Surrey, United Kingdom
Hypoxia correction improves survival in patients treated
with radiotherapy (RT) for some cancers. Previous
studies have shown the existence of hypoxia in untreated
prostate cancer (PCa) and hypoxia resolution following
carbogen breathing. Androgen deprivation therapy (ADT)
is normally given prior to RT. ADT is anti-angiogenic
and causes tumour vascular disruption. It is not known
whether the use of carbogen gas will still be effective
in correcting hypoxia post ADT. This study has assessed
this during hypoxia-modified RT.
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