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Abstract #1053

Magnetic resonance elastography of slow and fast shear waves illuminates differences in shear and tensile moduli in anisotropic tissue

John L Schmidt 1 , Dennis J Tweten 1 , Maisie M Mahoney 2 , Tally Portnoi 3 , Ruth J Okamoto 1 , Joel R Garbow 4 , and Philip V Bayly 1,2

1 Mechanical Engineering and Materials Science, Washington University, St. Louis, MO, United States, 2 Biomedical Engineering, Washington University, St. Louis, MO, United States, 3 Electrical Engineering, Massachusets Institute of Technology, Cambridge, MA, United States, 4 Biomedical Magnetic Resonance Laboratory, Department of Radiology, Washington University, St. Louis, MO, United States

In magnetic resonance elastography (MRE), mechanical properties are estimated by inversion of shear wave fields. Tissue properties are usually assumed to be isotropic and nearly incompressible, so that only one parameter (shear modulus) is obtained. In fibrous tissue, such as muscle or CNS white matter, tissue is anisotropic. The simplest anisotropic model is an incompressible, transversely isotropic model with three parameters: shear modulus (_2), shear anisotropy (ϕ) and tensile anisotropy (ζ). In this study, measurement of slow and fast shear wave speeds was performed by MRE of waves at specific angles relative to fiber direction, allowing estimation of these parameters.

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