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Abstract #1059

Viscoelasticity of Subcortical Gray Matter Structures

Curtis L Johnson 1 , Hillary Schwarb 1 , Matthew DJ McGarry 2 , Bradley P Sutton 1 , and Neal J Cohen 1

1 Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL, United States, 2 Thayer School of Engineering, Dartmouth College, Hanover, NH, United States

The mechanical properties of specific neuroanatomical regions estimated with magnetic resonance elastography (MRE) have shown promise in reflecting the presence of disease. In this work, we introduce a high-resolution MRE method for examining subcortical gray matter structures that is specifically designed to overcome issues arising from inadequate spatial resolution and proximity to cerebrospinal fluid. In a group of healthy young participants, we find differences in viscoelasticity between the hippocampus, thalamus, and putamen. Ultimately, such measurements may be critical for improved evaluation of aging and neurological disease by studying regions linked to functional decline.

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