Abstract #1065
Neuroprotective effects of Delayed Methylene Blue in Mild Traumatic Brain Injury
Lora Talley Watts 1 , Justin Alexander Long 1 , Qiang Shen 1 , and Timothy Q Duong 1
1
Research Imaging Institute, University of
Texas Health Science Center at San Antonio, San Antonio,
TX, United States
Methylene blue (MB) has energy-enhancing and antioxidant
properties. We previously showed that MB given one-hour
post TBI had neuroprotective effects in rats. This study
investigated the neuroprotective effect of delayed MB
treatment (24 hrs) as measured by lesion volume and
functional outcome. Comparisons were made with vehicle
and acute (1 hr) treatment. We found that delayed MB
treatment minimized lesion volume and functional
deficits compared to vehicle-treated animals. MB has an
excellent safety profile and is clinically approved for
other indications. MB clinical trials on TBI can thus be
readily explored.
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