Abstract #1079
Breast DCE with Fat Suppression: Enabling Quantitative Measurements
Maria A Schmidt 1 , Eva Kousi 1 , Araminta Ledger 1 , Erica Scurr 2 , Cheryl Richardson 2 , Georgina Hopkinson 2 , Elizabeth O'FLynn 1 , Steven Allen 2 , Romney Pope 2 , Robin Wilson 2 , and M Leach 1
1
CR-UK and EPSRC Cancer Imaging Centre, Royal
Marsden NHS Foundation Trust and Institute of Cancer
Research, Sutton, Surrey, United Kingdom,
2
Department
of Radiology, Royal Marsden NHS Foundation Trust,
Chelsea, London, United Kingdom
Breast Dynamic Contrast-Enhanced (DCE) examinations are
usually performed with fat suppression, providing
qualitative enhancement curves. In contrast,
pharmacokinetic modelling often uses spoiled
gradient-echo images and a proton density weighted image
as a reference to calculate T1 values. It would be
desirable to calculate T1 values from fat suppressed
clinical DCE examinations to quantify contrast-agent
uptake in longitudinal studies and to assess parenchymal
enhancement. In this work we introduce a reference image
of low flip angle and a calibration process, and
evaluate the accuracy of T1 values thus obtained. T1
measurements are viable in fat suppressed breast DCE.
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