Modelling vasculature and cellular restriction in breast tumours using diffusion MRI
Colleen Bailey 1 , Sarah Vinnicombe 2 , Eleftheria Panagiotaki 1 , Shelley A Waugh 2 , John H Hipwell 1 , Patsy Whelehan 2 , Sarah E Pinder 3 , Andrew Evans 2 , Daniel C Alexander 1 , and David J Hawkes 1
Centre for Medical Image Computing,
University College London, London, United Kingdom,
Cancer Centre, Ninewells Hospital and Medical School,
Dundee, United Kingdom,
Research Pathology, Research Oncology, King's College
London and Guy's Hospital, London, United Kingdom
We have examined regions of breast tumours using
diffusion MRI and fitting to compartment models that
characterize diffusion in the vascular, extracellular
and intracellular spaces. These were compared with
monoexponential apparent diffusion coefficient (ADC),
intravoxel incoherent motion (IVIM) and tensor models.
In the tumour center, diffusion ADC and IVIM best
explained the data, while tumour rim was best
characterized by a 3-compartment model including
isotropic restricted diffusion for the intracellular
component. This was in agreement with the low
cellularity in the tumour center and higher cellularity
in the rim observed on histology.
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