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Abstract #1082

Modelling vasculature and cellular restriction in breast tumours using diffusion MRI

Colleen Bailey 1 , Sarah Vinnicombe 2 , Eleftheria Panagiotaki 1 , Shelley A Waugh 2 , John H Hipwell 1 , Patsy Whelehan 2 , Sarah E Pinder 3 , Andrew Evans 2 , Daniel C Alexander 1 , and David J Hawkes 1

1 Centre for Medical Image Computing, University College London, London, United Kingdom, 2 Dundee Cancer Centre, Ninewells Hospital and Medical School, Dundee, United Kingdom, 3 Breast Research Pathology, Research Oncology, King's College London and Guy's Hospital, London, United Kingdom

We have examined regions of breast tumours using diffusion MRI and fitting to compartment models that characterize diffusion in the vascular, extracellular and intracellular spaces. These were compared with monoexponential apparent diffusion coefficient (ADC), intravoxel incoherent motion (IVIM) and tensor models. In the tumour center, diffusion ADC and IVIM best explained the data, while tumour rim was best characterized by a 3-compartment model including isotropic restricted diffusion for the intracellular component. This was in agreement with the low cellularity in the tumour center and higher cellularity in the rim observed on histology.

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