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Abstract #1096

High-resolution MRI analysis of breast cancer xenografts on the CAM @ 11.7T

Zhi Zuo 1,2 , Tatiana Syrovets 3 , Felicitas Genze 3 , Alireza Abaei 2 , Genshan Ma 4 , Thomas Simmet 3 , and Volker Rasche 1,2

1 Internal Medicine II, University Hospital Ulm, Ulm, Baden-Wurttemberg, Germany, 2 Core Facility Small Animal MRI, Medical Faculty, Ulm University, Ulm, Baden-Wurttemberg, Germany, 3 Institute of Pharmacology of Natural Products and Clinical Pharmacology, Ulm University, Ulm, Baden-Wrttemberg, Germany, 4 Department of Cardiology, Zhongda Hospital, Medical School of Southeast University, Nanjing, Jiangsu, China

High-resolution in ovo imaging is employed for monitoring the growth of human breast cancer cells grafted on the chorioallantonic membrane of chick embryos. High-resolution imaging is achieved by using an age-adopted precooling regime for immobilization of the chick embryo. The proposed scheme is proven safe for the chick embryo showing same survival rates as in a control group. The high-resolution MRI enables quantification of the tumor xenografts starting from d4 after grafting. A good correlation between tumor volumes derived by MRI and the weight of the tumor after extraction is shown.

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