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Abstract #1102

MR characterization of a syngeneic orthotopic ovarian tumor model

Marie-France Penet 1 , Balaji Krishnamachary 1 , Flonn Wildes 1 , Yelena Mironchik 1 , Chien-Fu Hung 2 , TC Wu 2 , and Zaver M Bhujwalla 1

1 JHU ICMIC Program, Division of Cancer Imaging Research, The Russell H Morgan Department of Radiology, The Johns Hopkins University School of Medicine, Baltimore, MD, United States, 2 Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD, United States

Epithelial ovarian cancer remains the leading cause of death from gynecologic malignancy among women in developed countries. Identifying mechanisms that drive the aggressiveness of ovarian cancers and its associated pathologies, such as the formation of metastases and the build-up of ascitic fluid, is urgently needed to provide new targets in effective control and treatment. Noninvasive magnetic resonance imaging (MRI) and magnetic resonance spectroscopic imaging (MRSI) provide opportunities to characterize the tumor microenvironment and to assess its relationship with ascites and metastases. We applied MRI and MRSI to better characterize ascites formation in a syngeneic orthotopic experimental model of ovarian cancer.

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