Correlation of Quantitative MRI-derived Tumor Characteristics with Histology in Breast Cancer Murine Models
Anna G Sorace 1,2 , Stephanie L Barnes 1,2 , Jennifer G Whisenant 1,2 , Mary E Loveless 1 , and Thomas E Yankeelov 1,2
Radiology and Radiological Sciences,
Vanderbilt University, Nashville, Tennessee, United
University Institute of Imaging Science, Vanderbilt
University, Nashville, Tennessee, United States
This study evaluated the relationship between the
apparent diffusion coefficient (ADC), the extravascular
extracellular volume fraction (
and quantitative histology measurements using two
preclinical breast cancer models, BT474 and MDA-MB-231.
Quantitative imaging biomarkers can reveal treatment
response, however better validation of the techniques
needs to occur prior to translation. While ADC reveals
significant correlations with the extracellular space in
both preclinical models, this data adds to the growing
body of literature which suggests that
not a reliable biomarker of extracellular space.
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