Meeting Banner
Abstract #1112

Investigating pH and other effects of a proton pump inhibitor (PPI) in cancer models with 31 P magnetic resonance

Gopal Varma 1 , Xiaoen Wang 1 , Han Xie 2 , Gerburg Wulf 3 , Pankaj Seth 2 , David C Alsop 1 , Aaron K Grant 1 , and Vikas P Sukhatme 2

1 Radiology, Division of MR Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States, 2 Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States, 3 Division of Hematology and Oncology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States

Proton pump inhibitors (PPIs) hold potential for treatment of cancer treatment by disrupting the transport of excess hydrogen ions out of cancer cells that maintains a normal intracellular pH and forms an acidic extracellular environment. The effect of a PPI combination on preclinical models of breast and non-small cell lung cancer was studied using slice-selective 31P spectroscopy through the tumor up to 40 minutes post drug injection. Intracellular pH decreased significantly following treatment. In addition, a more significant increase in Pi/╬│ATP ratio from pre- to post-injection periods was observed.

This abstract and the presentation materials are available to members only; a login is required.

Join Here