Abstract #1116
Assessing the utility of Oxygen-Enhanced Magnetic Resonance Imaging (OE-MRI) to predict radiation response of rat prostate Tumors
Derek A White 1,2 , Zhang Zhang 3 , Heling Zhou 1 , Debu Saha 3 , Peter Peschke 4 , Zhongwei Zhang 1 , and Ralph P Mason 5
1
Radiology, University of Texas Southwestern,
Dallas, Texas, United States,
2
Bioengineering,
University of Texas at Arlington, Texas, United States,
3
Radiation
Oncology, University of Texas Southwestern, Dallas,
Texas, United States,
4
Clinical
Cooperation Unit Molecular Radiooncology, German Cancer
Center, Heidelberg, Germany,
5
Radiology,
University of Texas Southwestern, Dallas, TX, United
States
Non-invasive prognostic biomarkers promise new insights
into tumor pathophysiology potentially allowing therapy
to be optimized. Notably hypoxia influences radiation
responses and Oxygen sensitive MRI (BOLD and TOLD) are
sensitive to tissue oxygenation. This study further
explores relationships between R1, R2* of rat prostate
tumors with respect to oxygen breathing challenge and
the tumor growth delay induced by a split dose radiation
regimen. Oxygen breathing was found to enhance tumor
growth delay and correlations were found with R1 and R2*
assessed before the first dose of radiation.
This abstract and the presentation materials are available to members only;
a login is required.
Join Here
