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Abstract #1120

Perfusion correlated heterogeneity in NSCLC patient tumor glucose metabolism

Christopher Hensley 1 , Eunsook Jin 2,3 , Naama Lev-Cohain 4 , Qing Yuan 4 , Kemp Kernstine 5 , Craig Malloy 6,7 , Robert Lenkinski 6,7 , and Ralph Deberardinis 8,9

1 Children's Research Institute, University of Texas Southwetern Medical Center, Dallas, Texas, United States, 2 Advanced Imaging Research Center, University of Texas Southwetern Medical Center, Texas, United States, 3 Internal Medicine, University of Texas Southwetern Medical Center, Texas, United States, 4 Radiology, University of Texas Southwetern Medical Center, Texas, United States, 5 Cardiovascular and Thoracic Surgery, University of Texas Southwetern Medical Center, Texas, United States, 6 Advanced Imaging Research Center, University of Texas Southwetern Medical Center at Dallas, Texas, United States, 7 Radiology, University of Texas Southwetern Medical Center at Dallas, Texas, United States, 8 Children's Research Institute, University of Texas Southwetern Medical Center at Dallas, Texas, United States, 9 Pediatrics, University of Texas Southwetern Medical Center at Dallas, Texas, United States

Significant inter- and intratumoral heterogeneity in in vivo glucose metabolism as assayed by [U-13C] glucose infusions exist in non-small cell lung cancer (NSCLC) patient primary tumors. We believe microenvironment-based advanced imaging methods can be used as pre-operative markers for intraoperative tumor fragment sampling to begin to study the magnitude of non-cell autonomous regulation of lung tumor metabolism. We demonstrate this proof of concept with DCE-MRI to assay the effects of heterogeneity in tumoral perfusion on both oxidative and non-oxidative NSCLC patient tumor glucose metabolism.

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